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Some studies imply that the nicotine in tobacco might have a protective effect, and nicotinelike drugs are being studied in the laboratory as potential therapies. Patients, however, would be foolish to take up smoking to try to slow disease SO-CALLED FROZEN ADDICTS posed together in 1991, after having received treatment. Nine years earlier all suddenly became immobile, as if they had instantly acquired Parkinson’s disease, after taking an impure version of a narcotic. Studies of how an impurity in the drug led to the freezing has generated many insights into the biochemical reactions that could contribute to a more classical presentation of the disease.

Tackling Turbulence with Supercomputers or greater. Interaction of these nonlinear variables generates a broad range of scales, which can make solving the equations exceedingly difficult. Specifically, in turbulence, the range of the size of whirling eddies can vary 1,000-fold or even more. There are other complicating factors as well, such as global dependence: the nature of the equations is that the fluid pressure at one point depends on the flow at many other points. Because the different parts of the problem are so interrelated, solutions must be obtained at many points simultaneously.

Understanding Parkinson’s Disease Shrinkage of handwriting is a symptom in some people. The samples show writing when a patient’s medicine was working (top) and when it was not (bottom). ALFRED T. KAMAJIAN (concept); BARRY ROSS (drawings) O f course, the best way to preserve neurons is to halt one or more key steps in the sequence of events that culminates in their destruction—if those events can be discerned. In the case of Parkinson’s disease, the collected evidence strongly implies (though does not yet prove) that the neurons that die are, to a great extent, doomed by the excessive accumulation of highly reactive molecules known as oxygen free radicals.

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